In 1996 he established the privatization fund Napredak Holding AD, through which he acquired shares in a number of companies in Bulgaria, operating in various industrial sectors.

One of these companies is the bicycles and forklift truck manufacturer Balkan AD, where the Domuschiev brothers’ mother – Margarita Domuschieva was appointed as Director in the period 1997 – 2009.

[6] In 1999 Kiril Domuschiev launched his own pharmaceutical business, establishing Huvepharma EOOD, which in 2000 privatized the then public company Biovet AD[7] – owner of a veterinary products factory in the town of Peshtera, Bulgaria.

Over the years Huvepharma EOOD constantly progressed to become a global pharmaceutical company focused on developing, manufacturing and marketing of human and veterinary medicine products.

Huvepharma markets its products through its own subsidiaries, Representative offices and Distributors and ranks among the top 10 global companies in the area of veterinary medicine.

The leading companies within Advance Properties OOD are doing business mainly in the fields of pharmaceutics, maritime transport, port operations, construction, realties, media, etc.

[11] In 2010 Kiril Domuschiev launched his own football project and began investing in the development of PFC Ludogorets 1945 EAD, in the town of Razgrad, Bulgaria.

The Board includes the best graduates of the university, distinguished experts in their field and well-known public figures with an active position and authority in society.

[18] In October 2018, Domuschiev's company Huvepharma received the Business of the Year Award for its contribution to the economic development of the City of St. Louis, Missouri, US.

[22] On January 20, 2020, Kiril Domuschiev was awarded with the "Winner’s Wreath" by the Sports Minister Krasen Kralev during a ceremony at the "Champion's Night".

[26] In December 2022, Domuschiev and Huvepharma were included with article in Fortune Global 500 ranking, where the company's environmental policy, energy saving efforts and implemented green technologies and processes are presented.