He is best known for his work on animated films, such as writing and directing Space Chimps (2008), The Croods (2013), Vivo (2021), and Ruby Gillman, Teenage Kraken (2023).

Raised in Wyckoff, New Jersey and a former resident of Franklin Lakes, DeMicco attended Ramapo High School.

After returning to the United States, he worked for the William Morris Agency in New York City, before relocating to the firm's office in Los Angeles in a transfer arranged by talent agent Lee Stollman.

[5] DeMicco's first script sale was called "A Day in November" which he sold to Warner Bros. and producer Arnold Kopelson for $1 million before signing to write Quest for Camelot.

John Cleese and DeMicco co-wrote the film adaptation of the Roald Dahl's children classic The Twits.

While working at Warner Bros., he and Du Chau also wrote a script for the upcoming live-action–animated film based on the Hanna-Barbera character, Hong Kong Phooey, which they sold to Alcon Entertainment.