His research also has addressed the influence of hydrology on the ecological dynamics of fluvial ecosystems and applications of this knowledge for managing aquatic biodiversity and freshwater resources in the United States and other regions of the world.
The E-P-O model predicts how spatial and temporal environmental variation influences selection for reproductive strategies, and further explains previously identified tradeoffs among demographic variables.
His extensive field studies, laboratory dietary and isotopic analyses, and quantitative innovations revealed that networks of predator-prey interactions were far more complex than had been previously described.
This body of work, together with his research on fish community ecology, reveals how functional traits influence the manner that organisms respond to abiotic and biotic environmental features.
Winemiller has been a proponent of the idea that universal form-function relationships and constraints result in widespread convergence of species adaptations and the structure of ecological communities in similar environments.