One of the founders of the kibbutz was Ami Saull, who was born in Manhattan 1932 (nephew of Israel Galili and father of filmmaker Dror Shaul).

Kissufim is part of the Shalom bloc of Israeli settlement meant to secure Israel's southern border with the Gaza Strip from the numerous Palestinian Fedayeen infiltrations.

[2] In 1999, Dror Shaul, who was born and raised on Kissufim, filmed a satirical comedy, Operation Grandma, based on life in the kibbutz.

In June 1977, a tractor-driver preparing a new field discovered mosaics believed to be part of the floor of a mid-sixth century Byzantine church.

[8] The nearby crossing into the Gaza Strip, named for the kibbutz, was the main route for traffic into the Gush Katif Israeli settlement bloc.