Tokyo Metropolis Saitama Prefecture Kiyose has a humid subtropical climate (Köppen Cfa) characterized by warm summers and cool winters with light to no snowfall.

[2] Per Japanese census data,[3] the population of Kiyose increased rapidly in the 1950s and 1960s with the development of many large-scale public housing projects, and has continued to grow at a slower rate in the decades since.

Archaeologists have found evidence of human settlement in the Kiyose area dating from over 20 thousand years ago, during the last glacial maximum.

During the Muromachi period, the area came under the control of Oishi Nobushige (大石 信重) from Saku in Shinano Province (now Nagano Prefecture).

The village of Kiyose was created within Kitatama District, Kanagawa by the merger of the hamlets of Kamikiyoto (上清戸), Nakakiyoto (中清戸), Shimokiyoto (下清戸), Kiyotoshitajuku (清戸下宿), Nakazato (中里), and Noshio (野塩) with the establishment of the modern municipalities system on April 1, 1889.

Whilst the incidence of the disease has greatly decreased, the city still has the second-most hospital beds after Chiyoda Ward.