Klasky Csupo was initially distinguished by its work on logo designs, commercials, feature film trailers, TV show titles, promos and ident spots for a wide variety of clients, in the process earning a reputation as the industry's most imaginative and innovative studio.

Building on its success, the studio left Seward Street to open its second facility in Hollywood in 1988 at the corner of Fountain and Highland Avenues.

In addition to the main title, Klasky Csupo was given the opportunity to produce and animate a new series of one-minute cartoons which featured a family called the Simpsons, created by Matt Groening.

Klasky Csupo produced and animated all 48 shorts, and when it became one of the most popular segments on the show, Fox began airing a weekly half-hour series entitled The Simpsons.

[18] Csupó was "asked [by Gracie Films] if they could bring in their own producer [to oversee the animation production]," but declined, stating "they wanted to tell me how to run my business.

"[18] Sharon Bernstein of The Los Angeles Times wrote that "Gracie executives had been unhappy with the producer Csupo had assigned to The Simpsons and said the company also hoped to obtain better wages and working conditions for animators at Film Roman.

[18] In 1991, Klasky Csupo created Rugrats, one of the first animated shows for Nickelodeon - known as "Nicktoons" - which was inspired by the couple's two sons and the idea of what they would do if they could speak.

[21] However, when Rugrats went into syndication, it exploded in popularity with ratings skyrocketing and advertising deals taking off, prompting Nickelodeon and Klasky Csupo to resume production on the series.

In 1993, Klasky Csupo worked with comedian Lily Tomlin and her partner Jane Wagner to bring the irascible little girl, Edith Ann, to television in two half-hour animated specials for ABC.

Created by Arlene Klasky and Gabor Csupo for CBS, Santo Bugito tells the story of a small town of 64 million insects located on the border of Texas and Mexico.

Class-Key Chew-Po had been an immediate success, building an impressive client list with work for companies like 1-800-COLLECT, Oscar Mayer, Taco Bell, Kraft, and Nickelodeon.

On December 23, 1998, CEO Terry Thoren concluded an eleven-month negotiation with the car industry Mercedes-Benz and moved the company into the state-of-the-art studio in Los Angeles.

In 2001, in honor of the tenth anniversary of Rugrats, Klasky Csupo released a two-part television special entitled All Growed Up, which featured all of the titular babies as teens.

Also in 2003, the studio began work on The Way the Dead Love, a theatrical film that was set to adapt seven short stories from German-American writer Charles Bukowski from a script penned by Bruce Wagner.

The project was then revived that same year at Warner Independent Pictures,[28] with Johnny Depp being attached to co-produce and serve as the voice of the film's main character.

[27] In 2005, the company again worked for Cartoon Network on the shorts Oogloo + Anju, Food Court Diaries, and The Topside Rag for Sunday Pants under Ka-Chew!.

In 2006, the longtime CEO of the company, Terry Thoren, left the studio and they dissolved the remainder of their 401(k) program, leading them to a period of dormancy and inactivity.

[33] In the same year, the studio released its final film to date, Immigrants, which was originally produced as an unaired animated series for Spike TV.

[39] At San Diego Comic-Con in 2016, Arlene Klasky explained that she would be willing to work on a revival of the series along with co-creators Gábor Csupó and Paul Germain.