[1] Running long distance can cause pain to the knee joint, as it is a high-impact exercise.

[21] Frank arthritis has been reported in children due to frostbite from extreme cold causing direct chondrocyte injury.

[23] A lower level of physical activity and a work environment where one is required to sit in a chair during the work day is one reason for developing knee joint pain, as the lower degree of physical movement tends to weaken the knee muscles.

[citation needed] As age progresses the movement of the knee joint involves higher friction with adjacent tissue and cartilages.

[32] Non-physical factors such as anxiety, depression, fear of movement, and catastrophizing are thought to have a linear correlation with increased pain experience and decreased physical function.

[33] The psychosocial factors may have either a positive or negative impact on adherence to rehabilitation programs for managing knee pain.