The club fielded teams in both Gaelic football and hurling.
The Knocktopher area was a Gaelic football stronghold at the turn of the 20th century.
The club won all four of its Kilkenny SFC titles in a ten-year period between 1901 and 1911, with clubman Dick Holohan also captaining Kilkenny to the Leinster SFC title in 1911.
[3] By the 1920s, Knocktopher was operating at junior level in both codes, winning the Kilkenny JFC title in 1924 and the Kilkenny JHC title in 1931.
A shortage of players saw Knocktopher and parish rivals Ballyhale amalgamating at underage levels, a move which resulted in the amalgamation reaching three successive Kilkenny MAHC finals in-a-a-row in the mid-1960s.