Knottsville is a small unincorporated community and census-designated place (CDP) in eastern Daviess County, Kentucky.

As a young man he moved to Daviess County, where he lived for a year in a small cabin on the Whitesville Road, and built in present-day Knottsville in 1827.

By the end of the 19th century, the town had two general stores, one drug store, one shoe shop, a blacksmith and wagon shop, two undertakers, one flouring mill, one saw and grist mill, and three tobacco factories.

St. William Catholic Church of Knottsville had the first public circulating library in Daviess County.

The early Catholic missionaries to the area were Fathers Charles Nerinx, Elisha J. Durbin, and Robert Abel.

Thomas F. Gambon, Vicar General of the Diocese of Louisville, and Father John Sheridan, Dr. Drury, J.B. and H.T.

Hazel, met to discuss the growing Catholic presence and the overcrowding at St. Lawrence Church.

Adjoining lots were purchased and the foundation of the present brick church was laid in the fall of 1887.

Timony's time here, an addition to the standing School and Library of St. William was made into a comfortable home for the sisters.

In April 1926 flames engulfed the school and the library that was attached there, along with the sister's residence housed in part of that building.

The building was paid for by then Governor Robert Hayes Gore of the Virgin Islands in memory of his mother, Mary Carrico, who was a former teacher at St. William elementary school.

In 2004 the building was razed due to new safety and fire code restrictions; the expense to renovate was considered financially unfeasible.

The Lamb of God sisters moved back into Owensboro where other members of their Order were stationed.