Knowsley North and Sefton East was a county constituency represented in the House of Commons of the Parliament of the United Kingdom.

The original Knowsley North constituency gained several wards from Crosby as a result of boundary changes in 1995.

The constituency covered the localities of Kirkby and Knowsley Village in Knowsley; Maghull, Lydiate, Lunt, Sefton Village, Ince Blundell, Waddicar and Melling and Aintree in Sefton.

It was bordered in the south by Knowsley South; in the west by Crosby; in the north by West Lancashire; in the southwest by Liverpool Walton, Liverpool West Derby, and Bootle and in the east by St Helens North and St Helens South.

Following decisions by the Boundary Commission for England, Knowsley North and Sefton East was abolished for the 2010 general election.