Knoxville is a neighborhood in southern Pittsburgh, Pennsylvania, United States.

Knoxville Borough was incorporated on September 7, 1877, from that part of Lower St. Clair Township adjoining Beltzhoover and Allentown.

Jeremiah Knox resided there in the early part of the nineteenth century, and established a fruit farm on the site.

Knoxville became accessible from the South Side in the 1870s with the opening of an incline, the Mount Oliver Incline, and then by an electric railway, the Pittsburgh, Knoxville & St. Clair Electric Railroad, in 1888.

[2] Knoxville has five borders, including the Pittsburgh neighborhoods of Allentown to the north, Carrick to the south, and Bon Air and Beltzhoover to the west.