In 2014, Brampton-based Loblaw Companies acquired Shoppers Drug Mart for $12.4 billion in cash and stock.

This includes 56 Shoppers Home Health Care stores (renamed to "Wellwise by Shoppers Drug Mart"), which sell and service assisted-living devices, home-care products, and mobility and medical equipment; Shoppers Drug Mart Specialty Health Network, a provider of specialty drug distribution, pharmacy and comprehensive patient support services; and MediSystem Technologies Inc., a provider of pharmaceutical products and clinical services to long-term care facilities and retirement communities.

[2] A new store concept, Wellwise, launched in fall 2017 as a single Toronto location; it sells healthy living products for seniors.

Koffler revamped the concept of the 20th century drug store in Canada by removing the soda fountain and emphasizing the dispensary, requiring his pharmacists to wear starched white coats as a symbol of their professionalism.

In 1974, Lord's Supervalue Pharmacies 26 stores in Atlantic Canada joined the Shoppers Drug Mart family.

That same year, David Bloom, a former Shoppers Drug Mart pharmacist, was appointed chief executive officer of the company.

During David Bloom's tenure, Shoppers doubled its number of stores, quadrupled its sales and increased profit ten-fold.

In November of that same year, Shoppers Drug Mart Corporation was publicly listed on the Toronto Stock Exchange.

In 2002, Shoppers Drug Mart introduced its first large format stores, with more space and a stronger focus on cosmetic products.

[14] In Summer 2018, Shoppers Drug Mart opened its flagship Toronto, Ontario location at Yonge-Dundas Square in the space formerly occupied by Hard Rock Cafe.

[16] On July 15, 2013, Loblaw Companies announced that it would acquire Shoppers Drug Mart for $12.4 billion, pending shareholder and regulatory approval.

In 2024, Shoppers Drug Mart was criticized for enacting sales quotas on pharmacists for MedsCheck, a government sponsored program in Ontario.

MedsCheck reimburses healthcare providers for medication reviews, allowing for a maximum billing of $75 per patient, which led to the profitability of enacting sales targets.