He was born in Ponnekallu village, near Tadikonda in Guntur district, Andhra Pradesh, India.
During the period, his dialogue delivery in an aptly modulated reverberating voice bought him wide recognition.
Subsequently, he acted in about 50 films, including Sri Krishna Pandaviyam, Thatha Manavadu (1972), and Samsaram Sagaram.
The film Tayaramma Bangarayya (1979), produced by Edida Nageswara Rao on the Poornodaya banner, was a hit.
Over a period of thirty years, Kommineni Seshagiri Rao directed around 30 films during his career.