[1][2] In 2002, she became the youngest woman ever to achieve the title of Grandmaster aged 15 years, 1 month, 27 days, a record only since surpassed by Hou Yifan.

In 1999, at the Asian Youth Chess Championship, held in Ahmedabad, she won the under-12 section, competing with the boys.

[10] Humpy competed with the boys in the 2004 World Junior Championship, which was won by Pentala Harikrishna and tied for fifth place, finishing tenth on countback with a score of 8.5/13 points.

[12][13] In 2005, she won the North Urals Cup, a round-robin tournament held in Krasnoturyinsk, Russia featuring ten of the strongest female players in the world at the time.

[14] She participated in the Women's World Chess Championship for the first time in 2004 and since then, she has competed in every edition of the event held with the knockout format.

In 2009, she tied for 1st–4th with Alexander Areshchenko, Magesh Panchanathan and Evgenij Miroshnichenko in the Mumbai Mayor Cup.

She won the individual bronze at the Women's World Team Chess Championship 2015 held in Chengdu, China.

Team India finished fourth in the competition – a point behind China, which won the bronze medal.

[22] Humpy competed at the 2022 Chess Olympiad as part of the women's India team, which achieved a bronze medal.