Konitsa acts as a regional hub for several small villages of Pindos, and features many shops, schools and a general hospital.

Primary aspects of the economy are agriculture and tourism; it is a popular starting point for tourists and hikers who want to explore the Pindos mountains, or who want to go rafting in the river Aoos or parapenting.

Due to Konitsa's closeness to places of particular interest, such as the Vikos–Aoös National Park, which includes the Vikos Gorge, the Aoos Gorge and the Tymfi mountains, where the Vikos spring water brand is collected, the Dragonlakes of Tymfi and Smolikas and the sulfur baths of Kavasila, contributed to the increase of tourism in the region.

At the time of the reign of Pyrrhus of Epirus (297–272 BC) a number of forts existed in strategically important positions.

The chronicle mentioned that the defences of the castle of Konitsa were strengthened by the local Despot of Epirus, due to an imminent attack.

These converts formed a powerful and influential group in the area, living in the upper part of Konitsa alongside the Christians.

[13] The functioning of the school was interrupted during the turbulent times of Ali Pasha's rule, however soon after it reopened following the initiative of Kosmas Thesprotos, a student of Athanasios Psalidas.

[2][23] In early November 1940, during World War II, the town witnessed a first short-term occupation by units from Fascist Italy.

[24] In the following Greek Civil War (1946–1949) the surrounding region became a major battleground, while in December 1947 communist guerrilla units unsuccessfully tried to capture the town.

[26] The communists guerrillas had the opportunity to withdraw and regroup to the People's Republic of Albania and then launch repeated attacks against Konitsa, but were decisively defeated by the Greek army.