[6][7] Mizzi was educated at the De La Salle College and completed his sixth form at the Paolino Vassallo Upper Lyceum.

Mizzi was awarded a Chevening Scholarship from the Foreign and Commonwealth Office in the United Kingdom and holds a Diploma in Finance.

[8] Mizzi has led major projects and initiatives across different sectors including public, infrastructure, telecommunications and enterprise promotion.

[8] Mizzi was a Partner and Head of the Energy and Infrastructure Practice for the EMEA Region (Europe, Middle East and Africa) with Pcubed, a global leader in programme management.

He has previously held senior roles with Deloitte and Touche and British Telecom (Programme Director) in the United Kingdom.

In the United Kingdom Mizzi led various change projects which included the forging of an Alliance between seven energy companies which improved services and realised large savings.

He was a consultant to the Office of the Prime Minister where he led a number of projects which, included the first public-private partnership to improve landscaping of the main roads in Malta.

[8] Mizzi was elected in the Maltese Parliament from the Fourth District (Paola, Gudja, Ghaxaq, Tarxien, Santa Lucija and parts of Marsa and Fgura) in March 2013.

[6] Immediately in his new role, he has set out an ambitious business and growth strategy for Air Malta, which builds on its current strengths including punctuality and good service.

One of the clear examples of decisions taken by the new Air Malta board appointed by Minister Konrad Mizzi, was the immediate re-introduction of the Frankfurt route.

The Minister made it also clear that Air Malta will be introducing new routes, and announced an increase in its fleet as part of the new commercial strategy being adopted.

The Minister together with Air Malta will in the coming months negotiate collective agreements, which will provide the airline with more flexibility that is required for growth and will also be fair to its employees.

[14] This saw the transformation of the energy in Malta, contrasting with the situation when Mizzi was given the responsibility when Enemalta was close to declare bankruptcy, with €840 million in debt and was consecutively downgraded by Standard & Poor's.

[15][16][17] In December 2014 Shanghai Electric signed an agreement with the Government of Malta[18] where it acquired a minority stake in the local energy producer Enemalta.

[18] In 2016, and following the investment by Shanghai Electric and the restructuring process that followed, Standard and Poor's upgraded Enemalta's rating to BB− with a stable outlook.

The Delimara Power and Gas project is being developed by Electrogas Malta Limited, a consortium that includes SOCAR, Siemens and Gem Holdings.

[28] Such concept enabled Malta to shift its financial resources onto other sectors, while simultaneously enjoying the benefits of modern and efficient infrastructure.

In 2015, there were no out of stock medicines registered in Malta under the Pharmacy of Your Choice scheme[40] Mizzi was appointed Minister for Tourism on 8 June 2017 following the 2017 General Election.

[42] Shortly upon assuming office, Mizzi claimed his priority over the next 12 months is to restructure the national airline and ensure it becomes financially viable before a strategic partner is roped in.

The airline later made announcements on several other new routes, namely Manchester, Casablanca, Lisbon, St Petersburg, Kiev and Venice.

[55][56] In order to handle enforcement, Mizzi has claimed that a 'multi agency team' will be introduced to ensure that there is better coordination and regulation of beaches before new concessions are granted.

[65] Mizzi said that the fund was solely intended to protect his family's assets, which include property in Malta and in London, a statement that was rubbished by the media.

[71] Public outcry related to the Mizzi's hidden offshore company later led to his resignation and was subsequently voted out of the Labour party on 23 June 2020.