[18][19] In 2015, Partners launched an electronic health record (EHR) system, allowing doctors, nurses, and other caregivers easier access patients' medical history.

[21][22] In 2019, 25 years after the founding of Partners, the health system made the decision to fully integrate the organization under the new name "Mass General Brigham".

Among the system's recent innovations: Visudyne for macular degeneration, Enbrel for rheumatoid arthritis, Eloctate and Alprolix for hemophilia, Entyvio for crohn's disease, and total joint replacements such as Durasul, Longevity, E1, and Vicacit-E.[15] In May 2000, CEO Dr. Samuel Thier and William C. Van Faasen, CEO of Blue Cross Blue Shield of Massachusetts—the state's biggest health insurer—agreed to a deal that raised insurance costs all across Massachusetts.

[69] They agreed that Van Faasen would substantially increase insurance payments to Mass General Brigham doctors and hospitals, largely correcting the underpayments of the previous 10 years.

[73] In April 2017, the United States District Court for the District of Massachusetts announced that Partners HealthCare System and one of its hospitals, Brigham and Women's Hospital, agreed to pay a $10 million fine to resolve allegations that a stem cell research lab fraudulently obtained federal grant funding.

Federal prosecutors commended the Brigham for disclosing allegations of fraudulent research at the lab and for taking steps to prevent future recurrences of such conduct.

The cost-cutting initiative was called Partners 2.0, and the plan looked to reduce costs in research, care delivery, revenue collection, and supply chain.

CEO Dr. David Torchiana said the job cuts were a financial necessity, adding that most sectors outsource call centers and back-office functions.

In response, the system announced its plan for a long-term sustainable future, which includes the following initiatives: Advancing integration to improve patient care and identify efficiencies, addressing the labor shortage by building workforce pipelines, and reducing expenses.