He graduated from the Yerevan Polytechnical Institute in 1932 and immediately began to work under the Armenian architects Alexander Tamanian and Nicholas G. Buniatyan (from 1933 to 1934 and 1934–1941, respectively).
[3] As an architect, Hovhannisyan designed many of the Soviet-style apartment buildings and community facilities that sprang around the city of Yerevan.
[3] In 1950, he was appointed the director of an excavation team that dug up the ancient Urartian fortress of Erebuni, located to the southeast of modern-day Yerevan.
It was Hovhannisyan who had initially identified Arin Berd as the location of Erebuni, based on inscriptions found adjacent to the city.
[4] Hovhannisyan used what was left of Erebuni as a basis for reconstructing the fortress and how it would have looked like when it was built in 782 B.C.