After the election of 1989 Andriessen was again appointed as Minister of Economic Affairs in the Cabinet Lubbers III, taking office on 7 November 1989.

Andriessen served as acting Minister of Transport and Water Management from 16 July 1994 until 22 August 1994 following the resignation Hanja Maij-Weggen.

After his retirement Andriessen returned to the private sector and public sector and occupied numerous seats as a corporate director and nonprofit director (ING Group, Hunter Douglas, Ballast Nedam, Elsevier, Diergaarde Blijdorp, Mittal Steel Company, Society for Statistics and Operations Research and the Internet Society) and serves on several state commissions on behalf of the government.

[citation needed] Andriessen held this position until 1965, when he joined the board of the Van Leer Group of Companies.

Andriessen has played an important role on the Supervisory Boards of such companies as Ballast Nedam, Elsevier, Randstad, ING Group, Hunter Douglas and Novograaf.