In classical antiquity location of present-day village was a part of a long Roman Danubian Limes three grave areals which were researched by archaeologists from Hungary before World War II, but two of them were destroyed in 1950 due to the dam construction.

[8] Village is mentioned one source from 1591 in the period of Ottoman rule over the medieval Kingdom of Hungary when it was waqf with 100 Hungarian families living on it.

Due to the proximity of Danube river and its backwaters fishing was an important economic activity with up to the 200 fishermen in the village at its peak.

[6] After the establishment of Kopački Rit nature park in 1976 fishing was limited so the importance of vegetable production increased.

[6] Village is located next to the Kopački Rit, one of the most important, largest and most attractive preserved intact wetlands in Europe.

[9] Local population of Kopačevo was among the first to accept Calvinism in the 16th century and village became important center of Protestantism in the region.