Kalfayan was admitted to the Schola Cantorum in Paris, France where he was taught by renowned music teacher and composer Charles Bordes and Vincent d'Indy.
[1] In 1905, he published a magazine called Kroonk and contributed to the Revue Artistique Armenienne in both French and Armenian.
On April 4, 1911, Kalfayan conducted his first concert which consisted of his musical works that he created in the Schola Cantorum de Paris.
After attaining his citizenship, he composed an American patriotic march entitled O America with lyrics by Alice Stone Blackwell.
Kalfayan gave concerts in New York City, Boston, Fresno, Los Angeles and San Francisco.