She has since starred in films such as BloodRayne (2005), in which she portrayed Rayne, Bounty Killer (2013), and Darkness of Man (2024), as well as the TV series Painkiller Jane (2007), The L Word (2007–2008) and Burn Notice (2011–2012).

[5][6] She is the daughter of Rande (née Porath), a model, and Merlin "Chris" Loken, a writer, apple farmer,[3] and former Broadway and Hollywood actor.

[12] In 2004, she appeared in a German television movie, Die Nibelungen (also known as "Dark Kingdom: The Dragon King" or "Sword of Xanten"), which aired as a two-part miniseries and set a ratings record.

Additionally, she starred as the title character in the Sci-Fi Channel's series Painkiller Jane which aired from April to September 2007.

In December 2011, Loken appeared in the fifth-season finale of the USA Network TV series Burn Notice as CIA agent Rebecca Lang, and would reprise that role in three sixth-season episodes during mid-2012.

[episode needed] In 2014, she starred in the action movie Mercenaries, alongside Cynthia Rothrock, Brigitte Nielsen, Vivica A.

"[13] On January 17, 2008, Loken announced on her website she was engaged to her Painkiller Jane co-star Noah Danby; the couple exchanged marriage vows at her family's farm on May 10, 2008.