[6][7] Alderson auditioned for the role of Starr Manning on One Life to Live in February 1998 and won the part, replacing Meghan Rayder.

[citation needed] On April 14, 2011, ABC announced the cancellations of both All My Children and One Life to Live, leaving General Hospital as the last remaining soap opera airing on the network after January 13, 2012.

[14] After One Life to Live finished filming on November 18, 2011, Alderson and her brother, who was also a OLTL cast member, turned down offers to reprise their roles in an online revival.

[15] On January 11, 2012, it was announced that Alderson and her former One Life to Live co-stars Kassie DePaiva, Michael Easton, and Roger Howarth, would reprise their roles on General Hospital.

TV Guide reported that the former One Life to Live actors would have to portray "characters that in no way resemble the current ones" in order to stay on General Hospital.

[1] In 2013, she received a Daytime Emmy Award for Outstanding Younger Actress in a Drama Series for her work as Starr on General Hospital.

[18] On September 24, 2013, Alderson was honored as "The Star of Tomorrow" by the ZEPHRA Magazine Recognition Awards and the city of West Hollywood issued a proclamation for the actress.

[citation needed] In 2014, she was nominated for a Daytime Emmy Award for Outstanding Younger Actress for her role as Kiki on General Hospital.

[19] On October 26, 2014, Alderson performed The Star-Spangled Banner at the University of Phoenix Stadium where the visiting Philadelphia Eagles faced the Arizona Cardinals.

[20] On January 10, 2015, Soap Opera Digest reported that Alderson had decided to depart General Hospital, opting to not renew her contract.

[23] Alderson starred as Cindy Lou in the Off-Broadway play, The Marvelous Wonderettes, in April 2018 at New York's Theatre Row.

[24] In June 2018, Alderson said that she would be open to returning to General Hospital as Starr Manning, because Prospect Park no longer owns the rights to One Life to Live characters.