Since then, she has established herself as one of the country's superstars,[1] achieving a subsequent level of prominence and recognition in the years that followed by starring in a number of beloved soap operas including Sana'y Wala Nang Wakas (2003), 'Til Death Do Us Part (2005), Gulong ng Palad (2006), Prinsesa ng Banyera (2007) and Dahil May Isang Ikaw (2009), which garnered a nomination at the prestigious International Emmy Awards and became a finalist in the 2011 New York Festivals TV & Film Award.

[2] Apart from being the second half of the groundbreaking and one of ABS-CBN's prime loveteams "EchoTin" (with Jericho Rosales), she has also been referred as one of the network's blockbuster queens, noted for having the "talent, commercial pull, and magic all combined to seize box-office.

She made her television comeback in the sitcom Hay, Bahay (2016) and returned to her mother network in 2018 to play an antagonist role in Bagani.

[8] Hermosa married actor and host Oyo Boy Sotto on January 12, 2011 at Club Balay Isabel in Banga, Talisay, Batangas with special sponsors Charo Santos-Concio and Johnny Manahan.

[9] They have five children - Kristian Daniel, 15, Ondrea Bliss, 12; Kaleb Hanns, 9; Marvic Valentin, 7; and Vittorio Isaac, 2 years old.

In 2000, she was cast in the primetime soap opera, Pangako Sa ’Yo, alongside Jericho Rosales.

Her last project on ABS-CBN was the action-fantasy series Noah where she played a diwata, the counterpart of a fairy in Philippine mythology.