He played in MLB for the Cincinnati Reds, Arizona Diamondbacks, Seattle Mariners, and Los Angeles Dodgers.

[3] He earned a baseball scholarship to UC Davis but lost it after one year due to poor grades.

[4] He was selected by the Boston Red Sox in the seventh round, 223rd overall, of the 2006 Major League Baseball draft.

[5] Negrón started his first professional season batting .234 in his first 25 games for the rookie class Gulf Coast League Red Sox.

[6] Negrón played three games for the Double-A Portland Sea Dogs during a brief July call-up and finished the season with the Lancaster JetHawks again.

[6] Negrón began 2012 with Louisville, but on June 6 he was called up for the first time to the Major Leagues, and made his Reds' debut the next day as a pinch-runner against the Pittsburgh Pirates.

[9] On June 14, he got his first Major League hit, a single off Scott Barnes, in the bottom of the fifth inning in Cincinnati.

[5] Negrón hit .218 with six homers and 20 RBIs at Louisville[6] until he tore the anterior cruciate ligament and medial meniscus in his right knee on July 5, costing him the rest of the season.

[6] In early July, he was called up to the big leagues for the second time in his career, replacing the injured Brandon Phillips.

[9] On July 13, Negrón, who started at second base, hit his first big-league home run off Francisco Liriano and tallied his first three RBIs against the Pittsburgh Pirates.

[12] His playing time was significant for the injury-ravaged Reds; he made the most of it with a three-game stretch against the Cleveland Indians August 5–7, going a combined 7–15 with two doubles, one home run and five RBIs.

[6] His season ended early when he suffered a partially dislocated shoulder, fractured scapula, and torn labrum while making a catch at Great American Ball Park on September 8.

[14] After spending the off-season rehabbing from his shoulder injury, Negrón signed a minor league contract with the Chicago Cubs that included an invitation to spring training on January 14, 2016.

[14] He spent the entirety of 2016 season with the Triple–A Iowa Cubs, where he hit .256/.308/.403 with nine home runs, 46 RBI, and 23 stolen bases across 117 games.

[9] He was outrighted off the roster after the season but re–signed with the team on a new minor league deal and was invited to spring training.

[6] On August 30, 2018, Negrón was traded to the Seattle Mariners for cash considerations[9] and he was added to the major league roster on September 1.

[5] On July 9, 2019, Negrón was traded to the Los Angeles Dodgers in exchange for minor league infielder Daniel Castro.