Her biggest break came when she landed the role of Anghelita in Mga Mata ni Anghelita, a remake of the 1978 Philippine movie of the same title (without the letter H on it) which made famous the late Julie Vega.
Art Angel again won Best Children's Show in the 2008 and 2009 PMPC Star Awards for Television.
Reyes was part of the 2013 remake of the 1996 hit TV series Anna Karenina with Barbie Forteza and Joyce Ching.
In March 2024, Reyes is engaged to her non-showbiz partner Lawrence dela Cruz.
"I’d like to hang out with you for my whole life," Krystal wrote in Instagram as he proposed to her in a resort in Basco, Batanes.