It is established by the Bangkok Metropolitan Administration (BMA), now it is a founding faculty of the recently founded University of Bangkok Metropolis (Navamindradhiraj University).
The History of the Kuakarun began when Vajira Hospital Nursing School (Thai: โรงเรียนพยาบาลผดุงครรภ์และอนามัยวชิรพยาบาล) was established in 1954, by the BMA Medical Department, centered in Vajira Hospital, in action to solve an insufficiency of nurses deployed in Bangkok's hospitals and health centers.
Later on, in 1970 BMA opened their second nursing school, stationed at BMA's General Hospital, called the General Hospital Nursing School (Thai: โรงเรียนพยาบาลโรงพยาบาลกลาง).
The new college is headquartered at the old Vajira Hospital Nursing School, but the campus has been renewed and expanded in time, to become one of the county's leading nursing schools today.
In early times the Kuakarun College of Nursing has been an affiliated institute of Srinakharinwirot University but has changed in 1993, after the BMA Medical College was founded, to be affiliated with Mahidol University.