While still an active amateur boxer, in October 2015 Kudratillo Abdukakhorov successfully made his professional debut, winning against his opponent ahead of schedule already in the third round.
At first, he performed exclusively at home, in particular, in March 2016, he won the vacant title of champion of Uzbekistan among professionals in the welterweight category, knocking out compatriot Islam Mirakhmedov.
Some of Abdukakhorov's best fights and notable victories include wins over Charles Manyuchi, Keita Obara, Sherzodbek Alimjanov, Luis Collazo, Javier Flores, Idd Pialari, and Romeo Jakosalem.
The last title was won by him in a duel with Zimbabwean Charles Manyuchi[5][6] (20-2-1), whom Abdukakhorov defeated by technical knockout in the first round.
In July 2017, at a tournament in Yekaterinburg, he met with Russian Dmitry Mikhailenko (22-1) — the confrontation between them lasted all the allotted 12 rounds, as a result, the judges unanimously gave the victory to Abdukakhorov, and he retained his WBC silver champion title.