Kunigunde was the youngest child of the Margrave Casimir of Brandenburg-Kulmbach (1481–1527) from his marriage to Susanne (1502–1543), daughter of the Duke Albert IV of Bavaria.
She married on 10 March 1551 in Neustadt an der Aisch with Margrave Charles II of Baden-Durlach (1529–1577).
When an imperial ban had been pronounced over her brother Albrecht II Alcibiades in 1554, Kunigunde took him into her residence in Pforzheim, where he died in 1557, a year before her death.
[2] She died in 1558 and was buried in the St. Michael Church in Pforzheim, where a cenotaph of the margravine can be found in the choir.
Baden came via her into the possession of the precious prayer book Gebetbuch der Markgräfin von Brandenburg, which Narziss Renner had created for her mother in 1520.