Kunigunde's parents were the Bohemian nobles Smil of Sternberg (d. 1431) and Barbara of Pardubice (d. 1433).

In 1441 she married the 21-year-old George of Poděbrady, who had been captain of the old Bohemian circle of Stará Boleslav[1] since 1440.

This marriage produced three sons: and three daughters: In 1444 Kunigunde founded a hospital in Poděbrady.

She also established a foundation for youth education, school construction and rehabilitation of prisoners.

She was buried in the parish church Exaltation of the Holy Cross in Poděbrady.