An 11-episode anime television adaptation directed by Takahiro Omori was produced by Brain's Base and aired on Fuji TV's Noitamina programming block between October and December 2010.

Princess Jellyfish centers on Amamizukan, an apartment building in Tokyo, where the only tenants are otaku women, and where no men are allowed.

Tsukimi hopes to become an illustrator and is an awkward girl terrified of social interaction, attractive people and the prospect of formal work.

Tsukimi meets the stylish Kuranosuke Koibuchi, the illegitimate son of a politician, who cross-dresses to avoid the obligations of politics and to feel closer to his mother.

Amamizukan's neighborhood is under threat of redevelopment, as opportunists aim to turn the quaint area into a more cosmopolitan region, with many of the buildings being demolished to make room for hotels and shopping centers.

Written and illustrated by Akiko Higashimura, Princess Jellyfish was serialized in Kodansha's josei manga magazine Kiss from October 25, 2008,[5] to August 25, 2017.

[7][8] Kodansha USA licensed and released the manga in North America in nine omnibus editions from March 22, 2016, to June 5, 2018.

In addition, the son of the original author, Akiko Higashimura (nicknamed Gocchan), makes a brief appearance as a background character in episode 8.

Funimation simulcasted the series on its video streaming website as part of their deal with Fuji TV; the first two episodes premiered on October 28, 2010.

[1] Crunchyroll staff also included it in such a list; reviewer Kara Dennison praised "its charming art to its heartfelt story" and said, "Princess Jellyfish is one of those rare precious gems that doesn't depict female otaku-dom as unicorn-rare, but digs into what it really feels like to be a young woman in that walk of life".