1835, Health, dated 29 November 1955, the government of Andhra passed orders to establish a medical college, the third one in the state at Kurnool.

When Andhra Pradesh was formed and the capital was shifted to Hyderabad from Kurnool the erstwhile secretariat building was handed over to the college.

Dr. C. Venkata Ramaiah was appointed as First Principal and Special Officer of Kurnool Medical College.

The first units in the major subjects of Medicine, Surgery and Midwifery were created in July 1957.

In the same year, the Government also established at this college, a Regional Laboratory to serve the needs of Raayalaseema districts.

Additional accommodation is shown in the hospital premises in improved sheds as sub hostel for women.

Rural health center for the teaching of social and preventive medicine was opened at Parla village in 1960.

During December 2006 and January 2007 students and faculty of this college were celebrating their Golden jubilee function.

[1] Officials concerned have also prepared designs and plans for new constructions to fast pace the work.

[1] These patients belongs to Kurnool and nearby districts and from neighbouring states of Telangana and Karnataka.

Additionally,recently a state level cancer institute has also been constructed in collaboration with Tata foundation in the premises.

Once the modernisation work gets completed Kurnool Government General Hospital will become the largest health care centre in Andhra Pradesh.