It borders Tbilisi, Shida Kartli, and Mtskheta-Mtianeti on the north; Samtskhe–Javakheti on the west; Kakheti on the east; and the countries of Armenia and Azerbaijan on the south.

The ethnic Georgians live mostly in northern part of the region and comprise the majority in the municipalities of Tetritsqaro, Gardabani, Tsalka and in Rustavi.

The Azerbaijanis live in the southern part and comprise for the majority in the municipalities of Marneuli, Dmanisi and Bolnisi.

[7] Kvemo Kartli is divided into 6 municipalities and 1 special status city, Rustavi: Owing to its location, the region has great transport links.

Kvemo Kartli inherited a lot of historical monuments such as the Bolnisi Sioni, the Pitareti Monastery, Birtvisi, Samshvilde and the old inhabited area near Dmanisi