He was the son of Justice Kwadwo Agyei Agyepong, one of three Ghanaian judges who was abducted and murdered during the early years of Ghana's Provisional National Defence Council.
He played roles in the campaigns of NPP Presidential Candidates Albert Adu Boahen in 1992, John Kufuor in 1996.
Kwabena Agyapong was one of 17 aspirants who contested for the party's nomination to replace John Agyekum Kuffuor as presidential candidate for the 2008 Ghanaian General Election,[2][3] In 2014, Kwabena Agyapong stood for the position of General Secretary for the Party and won.
[11] Prior to his death, Adam Mahama was alleged to have mentioned that Paul Afoko's brother, Gregory was one of those who assaulted and poured acid on him.
[12] Calls for Paul Afoko and Agyapong to be pushed out of the party, which started before the murder however continued to grow.
He attended the Mfantsipim School in Cape Coast and obtained a BSc Degree in Civil Engineering from the Kwame Nkrumah University of Science and Technology in Kumasi.