Kyainseikgyi (Phlone: ဍုံလာ့တ်ုကဝ်သၞေဝ်ဖါဍောဟ်; Burmese: ကြာအင်းဆိပ်ကြီးမြို့; pronounced [tɕàʔɪ́ɰ̃sʰeɪ̯ʔtɕí mjo̰]) is a town in Kayin State, Myanmar, located on the eastern side of the Zami River.

It is the administrative center of the Kyain Seikgyi Township.

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