He played in Major League Baseball (MLB) for the Toronto Blue Jays, Chicago White Sox, and Arizona Diamondbacks.

I know what to look out for because of him.He made four pitching appearances in the Gulf Coast League (for rookies) since his comeback from Tommy John surgery.

After a dominant start to the season with the High–A Clearwater Threshers, Drabek was promoted to the Double–A Reading Phillies on June 1, 2009.

[9] Drabek received the Paul Owens Award from the Phillies in a pregame ceremony at Citizens Bank Park on September 15, 2009.

[12] Drabek threw the second no-hitter in Double-A New Hampshire Fisher Cats history on Independence Day, 2010.

[15] Drabek attributed some of his success to a more consistent delivery, for which the point of release for different pitches appeared the same to batters.

His worst career outing occurred on June 1, 2011, when he lasted only 0.2 innings versus the Cleveland Indians.

In his June 13 start against the visiting Washington Nationals, Drabek "felt a pop in his elbow" during the fifth inning while pitching to Michael Morse.

With a one-ball, one-strike count on Morse, Drabek exited the game and was replaced by Aaron Laffey.

[25] On June 18, it was announced that Drabek would undergo Tommy John surgery for the second time in his career, ending his 2012 season.

[27] Drabek started his rehab assignment with the Class A-Advanced Dunedin Blue Jays on June 22, 2013.

[29] He was promoted to the Double-A New Hampshire Fisher Cats on July 29, and to the Triple-A Buffalo Bisons on August 14.

[30] He was recalled by the Blue Jays on September 3 after the Bisons' season ended, and the MLB rosters expanded.

[34] Drabek made his White Sox debut on Opening Day, and gave up a three-run home run to Alex Ríos.

[39] On July 12, 2016, the San Francisco Giants signed Drabek to a minor league contract to play shortstop.

[43] On March 21, 2017, Drabek signed with the Sugar Land Skeeters of the Atlantic League of Professional Baseball.

On July 17, 2018, Drabek signed with the Southern Maryland Blue Crabs of the Atlantic League of Professional Baseball.