He played college football for the Nebraska Cornhuskers and was selected by the Arizona Cardinals in the second round of the 2001 NFL draft.

[3] In his injury-abbreviated rookie season he finished with 12 tackles (6 solo), one quarterback sack, one hurry, one pass defended, and one fumble return for touchdown.

[4] In 2002, he returned from reconstructive knee surgery to lead Arizona with four quarterback sacks, nine hurries, and eight tackles for loss in 16 starts.

[6] In his first season with the Tennessee Titans in 2005, Vanden Bosch started all 16 games and made his first Pro Bowl after finishing second in the AFC and fourth in the NFL with 12.5 sacks.

On February 17, 2006 (only a week after his two-sack performance in the Pro Bowl), it was announced that Vanden Bosch had agreed to terms with the Tennessee Titans.

He was Named AFC Defensive Player of the Week after registering 12 tackles, three sacks and a forced fumble against New York Jets (December 23, 2007).

He played and started in 10 games and made 24 tackles and 4.5 sacks and finished fourth on the team with 18 quarterback pressures.

[8] The move reunited him with Jim Schwartz, his old defensive coordinator from Tennessee who at the time was head coach of the Detroit Lions.