[5][6] As a sophomore in 2016, he was named an All-American by the Football Writers Association of America (FWAA) and was a finalist for the Bronko Nagurski Trophy.

[7] Wilkins was part of the Clemson team that defeated top-ranked Alabama in the 2017 College Football Playoff National Championship by a score of 35–31.

[15] In Week 16 against the Cincinnati Bengals, Wilkins recorded his first career touchdown reception on a pass from Ryan Fitzpatrick in the 38–35 overtime victory.

[16] In Week 8 of the 2020 season against the Los Angeles Rams, Wilkins recorded his first career interception off a pass thrown by Jared Goff during the 28–17 win.

[19] In Week 15 of 2021 against the Jets, Wilkins lined up at fullback and recorded his second career touchdown on a flea flicker pass from quarterback Tua Tagovailoa.