L'Hospitalet-du-Larzac (French pronunciation: [lɔspitalɛ dy laʁzak]; Occitan: L'Espitalet de Larzac) is a commune in the Aveyron department in southern France, part of the southern Massif central, incorporating part of the Larzac plateau.

The economy is agricultural, notably dairy produce (Roquefort cheese), but also beef and mutton production, and rural tourism.

L'Hospitalet-du-Larzac is the site of discovery of one of the longest and most important inscriptions in the Gaulish language, a lead curse tablet (found in 1983).

The commune is named for a historical hospital founded by viscount Millau Gilbert (or Guibert) in 1108.

The current parish church dates to 1764, presumably built on top of an older structure.