Every story focuses on one city or building, and further explores a world where architects, urbanists, and ultimately "urbatects", are the leading powers and architecture is the driving force behind society.

[1] This fascination with architecture and the possible and impossible cities it can generate is further explored in The Gates of the Possible, a weekly series Schuiten created for the newspapers Le Soir and De Morgen in 2005.

Inspired by artists and scientists alike, Schuiten's work can be considered to mix the mysterious worlds of René Magritte, the early scientific fantasies of Jules Verne, the graphical worlds of M. C. Escher and Gustave Doré, and the architectural visions of Victor Horta and Étienne-Louis Boullée.

Schuiten also collaborated with Maurice Benayoun on the computer graphics series Quarxs, and worked as a production designer for a few movies: Gwendoline by Just Jaeckin, Mr. Nobody and Toto le héros by Jaco Van Dormael, Taxandria by Raoul Servais, The Golden Compass by Chris Weitz and Mars et Avril by Martin Villeneuve.

[2] He is currently working with Benoît Sokal and Martin Villeneuve on the script of Aquarica, a film that will use CGI and motion capture technology.