It consists of the cadastral territory of Líšeň (German: Lösch), originally a town that was annexed to Brno in 1944.

The heart of the old Líšeň is the Charles IV square, locally called "Městečko" (lit: 'little town').

The district office is located in a service complex on a housing estate near the Jírova transport hub.

After the demise of the Vizovice monastery at the end of the 15th century, it fell into secular possession, and in 1520 a separate Lišeň manor was established.

Among the frequently changing owners of the Lišeň estate were the gentlemen from Bořitová from Budeč, the Pergers from Perg, the Libštejns from Kolovratové and others.

[3] In 1714, Jan Kryštof of Freyenfels bought the estate from the Libštejn family, who had a new baroque castle built.

After the Freyenfels died out, the estate was inherited by the Belcredis, who held it until the abolition of the patrimonial administration in 1848.

[4] In the 19th century, the development of the predominantly agricultural Lišňa was hindered by insufficient communication links with Brno.

At the beginning of the 20th century, a great construction boom of the town began, which culminated during the First Republic.

During World War II, forced administration was imposed on the Belcredi estate in Lišeň.

), managed the Židenice lands and the Lišeň area of Malá Klajdovka at the time; while the second, based in Líšeň (gradually Brno XII, Brno XII-Líšeň or simply Líšeň), managed the rest of the territory of the modern Brno-Líšeň district and then also the Líšeň lands extending to the north side of the road in today's Hviezdoslavova street in the territory of the modern district Brno-Slatina.

In the northwest, Brno-Líšeň is adjacent to the municipality of Kanice, to the west, to the Brno-Vinohrady and Brno-Židenice districts; in the south with the city district of Brno-Slatina; in the southeast with the village of Podolí; in the east with the municipality of Mokrá-Horákov; and in the north with the village of Ochoz u Brna.

The northern part of the Lišné cadastre is covered with forests and the southern edge of the Moravian Karst protected area extends here.

Under socialism, Mariánské valley was renamed Gottwald's valley, and in the area built for that purpose, "peace celebrations" were held every year at the end of June, attended by local and national communist officials (for example, Gustáv Husák), popular singers (for example, Miroslav Žbirka) and there used to be various fairground attractions.