Proceeding due north, it bridges Ponchatoula Creek and forms a T-intersection with LA 3234 (University Avenue) on the west.

Additionally, it serves significantly as a farm-to-market road and, together with LA 442, facilitates recreational access to the Tangipahoa River.

LA 1065 is an old road, its original role in connecting Hammond and Independence having been assumed in the 1930s by US 51, which was in turn sidelined in the 1960s by I-55.

US 190 at that point was originally a two-way route entirely on Thomas Street in Hammond.

As an afterthought, traffic eastbound on US 190 has a sign reading "TO" LA 1065 with a left arrow.