LIH383 is an octapeptide and highly potent and selective agonist of the atypical chemokine receptor ACKR3 (CXCR7) that was derived from the opioid peptide adrenorphin.

[1][2][3][4][5] ACKR3 is a novel opioid receptor which functions as a broad-spectrum trap or scavenger for endogenous opioid peptides, including enkephalins, dynorphins, and nociceptin, and thereby acts as a negative modulator of the opioid system.

[3][4] By displacing them from ACKR3 and thereby increasing their availability, LIH383 potentiates the actions of endogenous opioids, for instance their analgesic effects.

[1][3][4][6] Other ligands of ACKR3 include conolidine, CCX771, RTI-5152-12, and VUF15485.

[1][6][7] This drug article relating to the nervous system is a stub.