[6] Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane,[7] and that is not the only function these channels have been linked to.

While LRRC8D is one of many proteins that can be part of VRAC, it is in fact one of the most important subunits for the channel’s ability to function; the other protein of importance is LRRC8A.

[10] This is where the other LRRC8 proteins come in, as the different composition of these subunits affects the range of specificity for VRACs.

[11][12] In addition to its role in VRACs, the LRRC8 protein family is also associated with agammaglobulinemia-5.

This article on a gene on human chromosome 1 is a stub.