LaSalle is a Buffalo Metro Rail underground station located at the corner of Main Street and LaSalle Avenue and is one stop from the northern terminus.

[2] The only visible sign of the turnout is located below ground by way of partially finished tunnel just west of the LaSalle station platforms.

LaSalle station is one of four stations that offers an off-road bus loop, requiring passengers to board/debark using curbside stops (the other three being University, Delavan/Canisius College and Utica) and one of only two that has only one route serving the station (the other being Humboldt-Hospital): In 1979, an art selection committee was created, composed of NFTA commissioners and Buffalo area art experts, that would judge the artwork that would be displayed in and on the properties of eight stations on the Metro Rail line.

Out of the 70 proposals submitted, 22 were chosen and are currently positioned inside and outside of the eight underground stations.

[3] LaSalle station is home of one piece of artwork, from Richard Gubernick of Buffalo.