The daughter of the former, Laura Honoré de Cuebas, was the author of the hymn of the University of Puerto Rico, Mayagüez Campus, which would be founded in 1911 by de Diego and she would give birth to a daughter of the same name, who would go on to teach there, in a hospital that would become the university's art museum.

[3][4] It was originally built for Santiago Sáenz y Martínez, who later passed it to José de Diego.

de Diego resided there for some years, as he was designated prosecutor and president of the Audiencia (Criminal Court) of Mayagüez in 1899 by General Brooke and three years later was elected as the representative for the House of Delegates.

The property is an urban mansion built in the "Modernist" located on a 716.82 m2 plot in the middle of a block, permitting the mansion to have a front entrance, to Liceo St., and a back entrance, facing Salud St.

On 2 April 2012, the Municipality of Mayagüez expropriated the property from Natalabriel, Inc., a tire business which owns the whole block, with the intention to establish a museum in the building commemorating the University of Puerto Rico at Mayagüez, since de Diego was a cofounder of the institution.