Administered by the School District of La Crosse, it is located on the south side of the city.

Originally, Central was located at the intersection of 16th and Cass Streets on La Crosse's south side, where Weigent Park stands today.

La Crosse Central High School has a variety of extra-curricular activities and athletics, and is part of the Mississippi Valley Conference.

Central's competitive show choir which was once called Grand Central Station, will now combine efforts with cross-town rival Logan High School to form a new combined show choir named “River City Revolution” which will start competing in the 2024-2025 school year.

GCS was undefeated in the 2001, 2002 and 2014 seasons and since 2015 has hosted its own competition, the Grand River Show Choir Invitational.