[3] La Crosse County's location in the United States' upper midwest gives the area a temperate, continental climate.

[19] La Crosse County has voted for the Democratic nominee in every presidential election since 1988.

[26] As a result of the 2020 presidential election, La Crosse County continued its Democratic trend by about 4% with a 13% lead over Republicans.

[28] La Crosse County is within the Wisconsin State Senate district 32, represented by Brad Pfaff (D).

It also contains Wisconsin State Assembly districts 95 Jill Billings (D) and 94 Steve Doyle (D).

Democrats also hold a majority of seats on the La Crosse County Board of Supervisors.