The Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2025–2029 categorized it as a non-hub primary commercial service facility.

One of the largest passenger jets, the Boeing 747 Air Force One (AF1), has made overnight trips to this airport with every U.S. President for the last 20 years [when?].

This was the last time a US President flew on this plane, which was retired to the National Museum of the United States Air Force in Dayton, Ohio.

In the past, Sun Country Airlines has flown DC-10 (380 passenger seats) on charter flights from La Crosse to other cities.

For the 12-month period ending December 31, 2022, the airport had 18,143 aircraft operations, an average of 50 per day: 70% general aviation, 26% air taxi / airline and 4% military.