The La Loche River is a tributary of the Ashuapmushuan River, flowing into the unorganized territory of Ashuapmushuan Lake, into the Regional County Municipality (RCM) of Le Domaine-du-Roy, in the administrative region of Saguenay-Lac-Saint-Jean, in Quebec, in Canada.

"La Loche River" flows in the townships of Le Ber, Cazeneuve, Mignault and Denault.

The surface of La Loche River is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.

The La Loche River originates at the mouth of Rivel Lake (length: 0.6 kilometres (0.37 mi), altitude: 401 metres (1,316 ft)) located in the township of Le Ber.

The toponym "La Loche River" was formalized on December 5, 1968, at the Commission de toponymie du Québec, when it was created.